Alan Anticevic, PhD

  • Assistant Professor of Psychiatry and of Psychology
  • Co-Director, Division of Neurocognition, Neurocomputation, and Neurogenetics (N3)

Dr. Anticevic trained in Clinical Psychology and Cognitive Neuroscience at Washington University in St. Louis where he worked with Drs. Deanna Barch and David Van Essen. Following his graduate training, Dr. Anticevic completed his internship in Clinical Neuropsychology at Yale University. After internship, he joined the Yale University Department of Psychiatry as research faculty while concurrently serving as the Administrative Director for the Center for the Translational Neuroscience of Alcoholism. Subsequently, he was appointed as an Assistant Professor of Psychiatry and Psychology at the Yale University School of Medicine, where he directs a clinical neuroimaging laboratory focused on severe psychiatric illness such as schizophrenia. Dr. Anticevic is a recipient of the NARSAD Young Investigator Award, the International Congress of Schizophrenia Research Young Investigator Award, the NIH Director's Early Independence Award, the NARSAD Independent Investigator Award and the Klerman Prize for Exceptional Clinical Research. He currently serves as the Co-Director of the Division of Neurocognition, Neurocomputation, and Neurogenetics (N3) at Yale School of Medicine.

Broadly, his research interests are centered on cognitive neuroscience of psychiatric illness, functional connectivity, as well as functional neuroimaging analysis methodology. Specifically, Dr. Anticevic is interested in characterizing brain circuits involved in cognitive operations such as working memory as well as their interaction with neural systems involved in affective processes, with the focus of understanding how these interactions may go awry in the context of severe neuropsychiatric illness (e.g. schizophrenia, bipolar disorder and substance abuse). Methodologically, his research harnesses the combination of task-based, resting-state, pharmacological functional neuroimaging, as well as computational modeling approaches to mechanistically understand neural circuit dysfunction in disorders such as schizophrenia.

Research interests
Affect; Cognition; Emotions; Memory, Short-Term; Schizophrenia; Substance-Related Disorders
Education
  • PhD, Washington University School of Medicine, St.Louis, 2011
  • MS, Washington University School of Medicine, St.Louis, 2007
Publications
  • Anticevic A*, Murray JD*, Barch DM. Bridging Levels of Understanding in Schizophrenia Through Computational Modeling. Clin Psychol Sci. 2015 May;3(3):433-459. PubMed PMID: 25960938; PubMed Central PMCID: PMC4421907. * Denotes shared 1st authorship.
  • Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7438-43. doi: 10.1073/pnas.1405289111. Epub 2014 May 5. PubMed PMID: 24799682; PubMed Central PMCID: PMC4034208.
  • Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biol Psychiatry. 2014 Apr 15;75(8):595-605. doi: 10.1016/j.biopsych.2013.10.021. Epub 2013 Nov 4. PubMed PMID: 24314349; PubMed Central PMCID: PMC3969771.
  • Cole MW, Repovš G, Anticevic A. The frontoparietal control system: a central role in mental health. Neuroscientist. 2014 Dec;20(6):652-64. doi: 10.1177/1073858414525995. Epub 2014 Mar 12. Review. PubMed PMID: 24622818; PubMed Central PMCID: PMC4162869.
  • Anticevic, A., Savic, A., Repovs, G., Yang, G., McKay, D.R, Sprooten, E., Knowles, E., Krystal, J.H. Pearlson, G.D., Glahn, D.C. Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2014). Ventral anterior cingulate connectivity distinguished non-psychotic bipolar illness from psychotic bipolar disorder and schizophrenia. Schizophrenia Bulletin. 41(1):133-43.
  • Anticevic A, Tang Y, Cho YT, Repovs G, Cole MW, Savic A, Wang F, Krystal JH, Xu K. Amygdala connectivity differs among chronic, early course, and individuals at risk for developing schizophrenia. Schizophr Bull. 2014 Sep;40(5):1105-16. doi: 10.1093/schbul/sbt165. Epub 2013 Dec 22. PubMed PMID: 24366718; PubMed Central PMCID: PMC4133672.
  • Anticevic A, Cole MW, Repovs G, Savic A, Driesen NR, Yang G, Cho YT, Murray JD, Glahn DC, Wang XJ, Krystal JH. Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Front Psychiatry. 2013 Dec 24;4:169. doi: 10.3389/fpsyt.2013.00169. PubMed PMID: 24399974; PubMed Central PMCID: PMC3871997.
  • Anticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, Savic A, Krystal JH, Pearlson GD, Glahn DC. Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness. Cereb Cortex. 2014 Dec;24(12):3116-30. doi: 10.1093/cercor/bht165. Epub 2013 Jul 3. PubMed PMID: 23825317; PubMed Central PMCID: PMC4224238.
  • Cole MW, Reynolds JR, Power JD, Repovs G, Anticevic A, Braver TS. Multi-task connectivity reveals flexible hubs for adaptive task control. Nat Neurosci. 2013 Sep;16(9):1348-55. doi: 10.1038/nn.3470. Epub 2013 Jul 28. PubMed PMID: 23892552; PubMed Central PMCID: PMC3758404.
  • Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends Cogn Sci. 2012 Dec;16(12):584-92. doi: 10.1016/j.tics.2012.10.008. Epub 2012 Nov 8. Review. PubMed PMID: 23142417; PubMed Central PMCID: PMC3501603.
  • Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Mol Psychiatry. 2013 Nov;18(11):1199-204. doi: 10.1038/mp.2012.194. Epub 2013 Jan 22. PubMed PMID: 23337947; PubMed Central PMCID: PMC3646075.
  • Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16720-5. doi: 10.1073/pnas.1208494109. Epub 2012 Sep 25. PubMed PMID: 23012427; PubMed Central PMCID: PMC3478611.
  • Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol Psychiatry. 2013 Mar 15;73(6):565-73. doi: 10.1016/j.biopsych.2012.07.031. Epub 2012 Sep 11. PubMed PMID: 22980587; PubMed Central PMCID: PMC3549314.
  • Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophr Res. 2012 Oct;141(1):8-14. doi:10.1016/j.schres.2012.07.007. Epub 2012 Aug 3. PubMed PMID: 22863548; PubMed Central PMCID: PMC3879404.
  • Cole MW, Yarkoni T, Repovs G, Anticevic A, Braver TS. Global connectivity of prefrontal cortex predicts cognitive control and intelligence. J Neurosci. 2012 Jun 27;32(26):8988-99. doi: 10.1523/JNEUROSCI.0536-12.2012. PubMed PMID: 22745498; PubMed Central PMCID: PMC3392686.
  • Anticevic A, Van Snellenberg JX, Cohen RE, Repovs G, Dowd EC, Barch DM. Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studies. Schizophr Bull. 2012 May;38(3):608-21. doi: 10.1093/schbul/sbq131. Epub 2010 Dec 1. PubMed PMID: 21123853; PubMed Central PMCID: PMC3329999.
  • Anticevic A, Repovs G, Dierker DL, Harwell JW, Coalson TS, Barch DM, Van Essen DC. Automated landmark identification for human cortical surface-based registration. Neuroimage. 2012 Feb 1;59(3):2539-47. doi: 10.1016/j.neuroimage.2011.08.093. Epub 2011 Sep 8. PubMed PMID: 21925612; PubMed Central PMCID: PMC3476835.
  • Anticevic A, Repovs G, Barch DM. Working memory encoding and maintenance deficits in schizophrenia: neural evidence for activation and deactivation abnormalities. Schizophr Bull. 2013 Jan;39(1):168-78. doi: 10.1093/schbul/sbr107. Epub 2011 Sep 12. PubMed PMID: 21914644; PubMed Central PMCID: PMC3523909.
  • Anticevic A, Repovs G, Corlett PR, Barch DM. Negative and nonemotional interference with visual working memory in schizophrenia. Biol Psychiatry. 2011 Dec 15;70(12):1159-68. doi: 10.1016/j.biopsych.2011.07.010. Epub 2011 Aug 20. PubMed PMID: 21861986.
  • Cole MW, Anticevic A, Repovs G, Barch D. Variable global dysconnectivity and individual differences in schizophrenia. Biol Psychiatry. 2011 Jul 1;70(1):43-50. doi: 10.1016/j.biopsych.2011.02.010. Epub 2011 Apr 15. PubMed PMID: 21496789; PubMed Central PMCID: PMC3204885.
  • Anticevic A, Repovs G, Barch DM. Emotion effects on attention, amygdala activation, and functional connectivity in schizophrenia. Schizophr Bull. 2012 Sep;38(5):967-80. doi: 10.1093/schbul/sbq168. Epub 2011 Mar 17. PubMed PMID: 21415225; PubMed Central PMCID: PMC3446234.
  • Anticevic A, Repovs G, Barch DM. Resisting emotional interference: brain regions facilitating working memory performance during negative distraction. Cogn Affect Behav Neurosci. 2010 May;10(2):159-73. doi: 10.3758/CABN.10.2.159. PubMed PMID: 20498341; PubMed Central PMCID: PMC3856369.
  • Anticevic A, Repovs G, Shulman GL, Barch DM. When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage. 2010 Feb 1;49(3):2638-48. doi: 10.1016/j.neuroimage.2009.11.008. Epub 2009 Nov 12. PubMed PMID: 19913622; PubMed Central PMCID: PMC3226712.
  • Anticevic A, Dierker DL, Gillespie SK, Repovs G, Csernansky JG, Van Essen DC, Barch DM. Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia. Neuroimage. 2008 Jul 1;41(3):835-48. doi: 10.1016/j.neuroimage.2008.02.052. Epub 2008 Mar 7. PubMed PMID: 18434199; PubMed Central PMCID: PMC2527864.
International activities
  • Applications of functional connectivity to the study of schizophrenia
    Chengdu, China (2013-Present)
    This collaborative project with Dr. Gong Qiyong focuses on using functional connectivity and other neuroimaging modalities to better understand the neurobiology of schizophrenia.

    West China Hospital, West China Hospital

  • Applications of functional connectivity to the study of 1st episode psychosis with Dr. Fei Wang
    China (2012-Present)
    This collaborative project with Dr. Fei Wang focuses on applications of functional connectivity to the study of 1st episode psychosis and individuals during more chronic phases of the illness.

    China Medical University, China Medical University

  • Simulation studies of global-based functional connectivity: dealing with individual variability in connectivity patterns
    Ljubljana, Slovenia (2010-Present)
    Ongoing method development collaboration.

    University of Ljubljana, University of Ljubljana

Current projects

Broadly, our group is interested in cognitive neuroscience of psychiatric illness. We seek to better understand, at the neural system level, the neural mechanisms behind cognitive and affective deficits in neuropsychiatric illness. Specifically, the research in our group focuses on understanding these processes in schizophrenia, bipolar illness and addiction. We use a combination of tools to better understand the neural systems involved in processing affective stimuli and their interaction with neural systems involved in goal-directed cognitive operations such as working memory. Methodologically, our lab harnesses the combination of task-based, resting-state, pharmacological functional neuroimaging, as well as computational modeling approaches to mechanistically understand neural circuit dysfunction in psychiatric disorders. Our experimental approaches depend on the combination of these tools to better understand the mechanistic links between neural circuit dysfunction and complex cognitive and affective processes and behaviors. The overarching objective of the lab is better understand the underlying neural circuit dysfunction in complex mental illness such as schizophrenia, with the aim of developing better neural markers and informing rationally-guided pharmacological treatments.

Research Areas

Area 1: Pharmacological Neuroimaging & Computational Modeling

Area 2: Cognition-Emotion Interactions in Psychiatric Illness

Area 3: Functional Connectivity & Individual Differences in Psychiatric Illness

Honors
  • A.E. Bennett Research Award
  • Klerman Prize for Exceptional Clinical Research
  • NARSAD Independent Investigator Award
  • Janet Taylor Spence Award For Transformative Early Career Contributions
  • International Congress on Schizophrenia Research - Young Investigator Award.
  • NARSAD Young Investigator Award
  • 2012 NIH Director's Early Independence Award
  • James Hudson Brown-Alexander B. Coxe Research Fellowship in Medical Sciences
  • Cold Spring Harbor Computational & Cognitive Neurobiology Workshop Fellowship
Services
  • YCRC is jointly chaired by the Deputy Provost for Research, the YSM Deputy Dean for Academic & Scientific Affairs, and the Chief Information Officer. This committee will steer the intellectual direction of the YCRC and advise on budgetary matters. More generally, the committee will guide strategy, direction and decision making regarding the use and support of computational research technologies, and it will help set priorities for the YCRC.
    Yale Center for Research Computing (YCRC) Steering Committee
Languages
Croatian